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The prefrontal cortex (PFC) and the limbic system (including the amygdala, hippocampus, and cingulate gyrus) are the primary brain regions implicated in bipolar disorder’s pathophysiology, showing both structural and functional abnormalities. 

Location: 3.9 Integrated Neurobiology Quiz

The prefrontal cortex (PFC) and the limbic system (including the amygdala, hippocampus, and cingulate gyrus) are the primary brain regions implicated in bipolar disorder’s pathophysiology, showing both structural and functional abnormalities. 

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